Early-stage data on Astra Zeneca COVID vaccine due Monday: Lancet


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▴ Early-stage data on Astra Zeneca COVID vaccine due Monday: Lancet
Early-stage human trial data on a vaccine being developed by AstraZeneca and Oxford University will be published on July 20.

The Lancet medical journal said on Wednesday it will publish keenly-awaited phase 1 clinical trial data on a potential COVID-19 vaccine being developed by AstraZeneca and Oxford University on Monday.

“We expect this paper, which is undergoing final editing and preparation, to be published on Monday, July 20, for immediate release,” a spokeswoman for the journal said.

Recently, the company reached an agreement with Europe’s Inclusive Vaccines Alliance (IVA), spearheaded by Germany, France, Italy and the Netherlands, to supply up to 400 million dosesy of the University of Oxford’s potential COVID-19 vaccine, currently in clinical development.

With today’s agreement, the IVA aims to accelerate the supply of the potential vaccine and to make it available to other European countries that wish to participate in the initiative. The IVA is committed to providing equitable access to all participating countries across Europe.

AstraZeneca continues to build a number of supply chains in parallel across the world, including for Europe. The Company is seeking to expand manufacturing capacity further and is open to collaborating with other companies in order to meet its commitment to support access to the vaccine at no profit during the pandemic.

Pascal Soriot, Chief Executive Officer, said: “This agreement will ensure that hundreds of millions of Europeans have access to Oxford University’s vaccine following approval. With our European supply chain due to begin production soon, we hope to make the vaccine available widely and rapidly. I would like to thank the governments of Germany, France, Italy and the Netherlands for their commitment and swift response.”

The Company has recently completed similar agreements with the UK, US, the Coalition for Epidemic Preparedness Innovations and Gavi the Vaccine Alliance for 700 million doses, and it agreed on a license with the Serum Institute of India for the supply of an additional one billion doses, principally for low-and-middle-income countries. Total manufacturing capacity currently stands at two billion doses.

Oxford University last month announced the start of Phase II/III UK trial of AZD1222 in about 10,000 adult volunteers. Other late-stage trials are due to begin in a number of countries. AstraZeneca recognizes that the potential vaccine may not work but is committed to progressing the clinical programme with speed and scaling up manufacturing at risk.

The Company’s comprehensive pandemic response also includes rapid mobilization of AstraZeneca’s global research efforts to discover novel coronavirus-neutralising antibodies to prevent and treat the progression of the COVID-19 disease, with the aim of reaching clinical trials in the next three to five months. Additionally, the Company has quickly moved into the testing of new and existing medicines to treat the infection, including the CALAVI trials underway for Calquence (acalabrutinib) and the DARE-19 trial for Farxiga (dapagliflozin) in COVID-19 patients.

 

Tags : #Lancet #OxfordUniversity #OU #AstraZenecaNews #Calavi #Farxiga #InclusiveVaccineAlliance #PascalSoirot #Calquence #GaviVaccineAlliance

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