ARCI develops earth based magnetocaloric material for cancer treatment

▴ magnetocaloric-material-provide-controlled-heating-kill-tumor-cell
Magnetocaloric materials can provide controlled heating required to kill the tumor cells

Scientists at the International Advanced Research Centre for Powder Metallurgy and New Materials (ARCI), an autonomous R&D Centre of Department of Science and Technology (DST) has developed a rare-earth-based magnetocaloric material that can be effectively used for cancer treatment. The magnetocaloric materials (certain materials in which application and removal of a magnetic field causes the materials to become warmer or cooler) developed by ARCI are being tested at Sree Chitra Tirunal Institute for Medical Sciences & Technology (SCTIMST). A paper on the research work has been published in the Journal of Alloys and Compounds.

Advancements in magnetic materials led to the development of magnetic hyperthermia to try to address the issues of side effects of cancer treatment like chemotherapy. In magnetic hyperthermia, magnetic nanoparticles are subjected to alternating magnetic fields of few Gauss, which produce heat due to magnetic relaxation losses. Usually, the temperature required to kill the tumor cells is between 40 and 45°C. However, the drawback in magnetic hyperthermia is the lack of control of temperature, which may damage the healthy cells in the body and also have side effects like increased blood pressure etc.

These problems can be avoided by using magnetocaloric materials, as it can provide controlled heating. The advantage of magnetocaloric materials which heat up or cool down with the application and removal of the magnetic field, respectively is that as soon as the magnetic field is removed, cooling effect is generated, unlike in magnetic nanoparticles where overheating persists, even after removal of the magnetic field.

The team at ARCI chose rare-earth-based alloy for studies as some of the rare earth materials are human body compatible. They optimized the alloy composition so that the Curie temperature came close to the therapeutic range (i.e. 42-460C) required for destroying cancer cells. Preliminary hyperthermia measurements were carried out using Ambrell EASY HEAT laboratory induction heating system for 15 minutes; with temperature measured every 1 minute at SCTIMST.

With the application of the magnetic field on dry powders, the temperature of the rare-earth nanoparticles rose to 590C. To simulate injection into tumour, particles were dispersed in distilled water, and the temperature was found to be 380C. It is expected that the heating capacity would increase with the increase in the magnetic field. ARCI and SCTIMST are carrying out vitro measurements on the tumour cells with rare-earth nanoparticles dispersed in fluids for testing with MRI at a higher magnetic field of 0.5 Tesla to generate more data.This method, when used in conjunction with radiation therapy, would reduce the side effects, damage caused to the human body and also reduce the treatment time of cancer tumours.

Tags : #Cancertreatment #Chemotherapy #RadiationTherapy #SCTIMST

About the Author


Team Medicircle

Related Stories

Loading Please wait...

-Advertisements-



Trending Now

Actor-Director Sathish Kaushik Died of a Heart Attack at the Age of 66March 09, 2023
Soleus Push-Ups: A Laziest Exercise to Lower Blood Sugar LevelsMarch 09, 2023
World Kidney Day 2023: Be Aware of Kidney DiseasesMarch 09, 2023
Sushmita Sen reveals about suffering from a severe heart attack recently and Addison's disease in 2014March 06, 2023
A significant increase in influenza A H3N2 patients that are accompanied by severe coughing and feverMarch 06, 2023
Is AIDS or HIV curable in Ayurveda?March 03, 2023
Artificial Sweetener Erythritol Raises the Possibility of Heart Attack.March 01, 2023
Difference between HIV and AIDS - When to give antiretroviral therapy?March 01, 2023
Zero Discrimination Day: Let's Raise the Voice Against DiscriminationMarch 01, 2023
International Women’s Day 2023 – Embrace EquityFebruary 28, 2023
Brain Tumors - Types, Symptoms and Risk FactorsFebruary 28, 2023
World Rare Disease Day: End Stigma Against Rare Diseases.February 28, 2023
National Science Day 2023 - Global Science for Global WellbeingFebruary 28, 2023
Eating disorders - Types and their complicationsFebruary 27, 2023
The condition that took away the life of Malayalam filmmaker, Joseph ManuFebruary 27, 2023
World NGO Day 2023 - We make a living by what we get, but we make a life by what we giveFebruary 27, 2023
Functions and Problems of SerotoninFebruary 25, 2023
Arthritis management – Tips to manage arthritis effectivelyFebruary 25, 2023
Apple has undertaken a project of no-prick blood sugar monitoring feature for its watch.February 24, 2023
Bird flu – Jharkhand on alert, know its prevention and symptoms in humansFebruary 24, 2023