One in five deaths around the world is caused by sepsis, also referred to as septicemia, which shows the foremost comprehensive analysis of the condition.
The report estimates 11 million people a year are dying from sepsis - quite are killed by cancer.
University of Washington researchers said the "alarming" figures were double previous estimates.
Most cases were in poor and middle-income countries, but even wealthier nations are handling sepsis.
The biggest killer you'll not know
How good are hospitals at treating 'hidden killer'?
What is sepsis?
Sepsis is additionally referred to as the "hidden killer" because it is often so hard to detect.
It is caused by the system going into over-drive. rather than just fighting an infection, it starts attacking other parts of the body too.
Ultimately it causes organ failure. Even survivors are often left with long-term damage and disability.
The viruses and bacteria that cause diarrhea or lung ailments are primary triggers of sepsis.
Why the jump in numbers?
Previous global estimates, which came up with a figure of 19 million cases and 5 million deaths, were supported just a couple of western countries.
This analysis, published within the Lancet and supported medical records from 195 nations, shows there are 49 million cases a year.
The 11 million deaths from sepsis account for one in five of all deaths around the world.
The good news during this analysis is that cases and deaths have fallen since 1990.
The hope is knowing the truth scale of the matter will raise awareness and save more lives.
Who is affected?
People from Low- and middle- income countries amount to 85 percent cases.
Children were most in danger with four in 10 cases in children under the age of 5.
But even within the UK, sepsis may be a challenge. The death rate is above in countries like Spain, France, and Canada.
There are around 48,000 deaths from sepsis within the UK annually, the report shows.
There has been an enormous push within the health service to spot the signs of sepsis more quickly and to start treatment.
What is often done?
Reducing the number of infections can reduce the number of cases of sepsis. For many countries, this suggests good sanitation, clean water and access to vaccines. The other challenge is to urge better at identifying patients with sepsis so as to treat them before it's too late. Early treatment with antibiotics or anti-virals to clear an infection can make a huge difference.
What are the symptoms?
In adults: slurred speech extreme shivering or muscle pain Passing no urine during a day severe breathlessness high pulse and high or low blood heat skin mottled or discolored children a mottled, bluish or pale appearance very lethargic or difficult to make abnormally cold to the touch breathing in no time a rash that doesn't fade once you press ita seizure or convulsion.