Xencor, Inc., a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies for the treatment of cancer and autoimmune diseases, and The University of Texas MD Anderson Cancer Center announced a strategic collaboration to study investigational treatments for patients with a variety of cancer types. The parties will collaborate to design and execute additional clinical studies with Xencor’s portfolio of XmAb drug candidates, including novel bispecific antibodies and engineered cytokines. Xencor is committing to funding and supporting these studies over an initial five-year term.

“MD Anderson is a leader in clinical research for both hematological and solid tumor oncology, and we are excited to enter this broad collaboration,” said Allen Yang, M.D., Ph.D., senior vice president and chief medical officer at Xencor. “This alliance partnership will enable us to expand our ongoing efforts into additional indications, generate new clinical insights, inform key decisions and accelerate development timelines across our oncology portfolio. We look forward to working closely with MD Anderson as we advance new therapies to patients in need.”

Xencor’s clinical-stage bispecific antibodies and cytokines are engineered with a heterodimer Fc domain (antibody tail), which enables their rapid design, simplified development and stable structure. Nine XmAb bispecific antibodies and one engineered cytokine are being evaluated in Phase 1 clinical studies conducted by Xencor and its partners:

“Xencor’s portfolio of novel antibody-based therapies offers a unique opportunity to evaluate a variety of clinical hypotheses for improved cancer treatments,” said Christopher Flowers, M.D., ad interim division head of Cancer Medicine at MD Anderson. “By working collaboratively, we aim to identify potential benefits for many patients with hematologic cancers and solid tumors.”

About Xencor, Inc.

Xencor is a clinical-stage biopharmaceutical company developing engineered monoclonal antibodies for the treatment of cancer and autoimmune diseases. Currently, 18 candidates engineered with Xencor's XmAb® technology are in clinical development internally and with partners. Xencor's XmAb antibody engineering technology enables small changes to the structure of monoclonal antibodies resulting in new mechanisms of therapeutic action. For more information, please visit www.xencor.com.

About MD Anderson

The University of Texas MD Anderson Cancer Center in Houston ranks as one of the world's most respected centers focused on cancer patient care, research, education and prevention. The institution’s sole mission is to end cancer for patients and their families around the world. MD Anderson is one of only 51 comprehensive cancer centers designated by the National Cancer Institute (NCI). MD Anderson is ranked No.1 for cancer care in U.S. News & World Report’s “Best Hospitals” survey. It has ranked as one of the nation’s top two hospitals for cancer care since the survey began in 1990, and has ranked first 16 times in the last 19 years. MD Anderson receives a cancer center support grant from the NCI of the National Institutes of Health (P30 CA016672).