India's indigenous solution to COVID-19 in progress

▴ India's indigenous solution to COVID-19 in progress
Monoclonal antibody leads for COVID-19: A way forward In combating COVID-19

To fight the Novel coronavirus SARS-COV-2, the virus behind the worldwide outbreak of COVID-19 disease, a Nagpur based Indian biotechnology company, GeNext Genomics, is contributing by isolating the antibody gene pool of the cured COVID-19 patients that will unravel target antibodies for neutralizing SARS-COV-2. The therapeutic antibody is a bullet-like drug which targets and neutralizes the virus. One of the core biological characteristics of SARS-CoV-2 is the presence of spike proteins that enable this virus to invade host cells through its receptor binding domain (RBD) and cause infection. RBD is a crucial region on the virus's spike protein which is being evaluated for identifying inhibitory/neutralizing molecules. The GNG team isolated the antibodies from a diverse gene pool which were phage displayed and panned through RBD and spike proteins of SARS-COV-2.

Using its proprietary Antibody Library Platform, GNG has successfully identified a few strong binders that will soon be evaluated for its efficacy towards target and developing a potential future therapy. Currently, the team is characterizing these binders for neutralization and efficacy against SARS-COV-2. The development would go in phase-wise manner with collaboration for pre-clinical and clinical studies. GNG hence aims to build a therapeutic monoclonal antibody neutralizing RBD domain.

Speaking on the development Supriya Kashikar, Founder & CEO, GeNext Genomics said "GNG is working towards developing an indigenous solution to COVID-19 by identifying Monoclonal Antibody Binders from cured Patients of COVID-19". She further added that "Monoclonal Antibody has a huge potential in formulating a biologic drug for SARS-COV-2." She also added that, "Our Prime Minister addressed the scientific fraternity to work towards this pandemic and that has triggered us to use our expertise and try to bring out the solution. This is just the first milestone but we will fast track it to successful lead development."

Currently, monoclonal antibody-based therapy for COVID-19 has been approved by FDA for emergency. GeNext Genomics aims to build a therapeutic valued antibody which will be much efficacious than current approved therapy. Although drug discovery is a long journey, the scientists at GNG aim to complete the molecule validation and antibody development by early 2021.

Apart from COVID-19 therapeutic target validation, GNG is also developing Biosimilar Clone of Golimumab under National Biopharma Mission. GNG aims to develop a therapeutic pipeline gradually and make India self-sustained with its discovery and solutions for healthcare.

Tags : #GeNextGenomics #LatestNewsonGeNextGenomics19thNov #LatestPharmaNews19thNov #SolutiontoCOVID-19 #LatestNewsonCOVIDTreatment19thNov #FightAgainstCorona #USFDA #India #Nagpur

About the Author


Team Medicircle

Related Stories

Loading Please wait...

-Advertisements-




Trending Now

Is Your Cooking Oil Poisoning You? The Truth About Seed OilsMarch 11, 2025
Think Before You Bite: How Fatty Foods Can Trigger Brain Damage in Just 3 DaysMarch 11, 2025
Ditch the Pills: The Secret to Beating Insomnia is in Your WorkoutMarch 11, 2025
The University of Tasmania invites applications for Master of Public HealthMarch 11, 2025
CBM India Celebrates International Women's Day with Free Eye Screening in HyderabadMarch 11, 2025
Is patriarchy petrifying governments to deliver on gender equality?March 11, 2025
Change happens when gender inequality survivors join hands to stop TB March 10, 2025
Arogya World Hosts #RunInRed With 1500+ Bengalureans To Raise Awareness on Women’s Heart HealthMarch 10, 2025
Sharda Group Launches Sharda Care - Healthcity, a State-of-the-Art Facility with Smart Infrastructure in Greater NoidaMarch 10, 2025
Can Just Three Days of Junk Food Harm Your Brain? Science Says YesMarch 08, 2025
Your Night Shifts Might Be Damaging Your DNA: Here’s How to Fight BackMarch 08, 2025
India’s Women: Empowered on Paper, Struggling in RealityMarch 08, 2025
NephroPlus to Launch Nationwide Free Health Screening Campaign to Commemorate World Kidney Day 2025 March 07, 2025
Skinny But Sick? Is our Body Mass Index Misleading UsMarch 07, 2025
Scientists Stumble Upon a Cancer-Fighting Secret Hidden in Your Medicine CabinetMarch 07, 2025
The Bitter Truth About Butter: Is our Favourite Spread Cutting our Life Short?March 07, 2025
March 07, 2025
March 06, 2025
University of Leeds scientists offer hope for people facing chronic painMarch 06, 2025
Impact of excessive use of gym supplements on gym enthusiastsMarch 06, 2025