Diabetes drug may help to prolong preterm pregnancies in women with pre-eclampsia

Further trials needed to confirm results, but researchers “cautiously optimistic” that treatment of preterm pre-eclampsia is possible

Giving the drug metformin to women diagnosed with preterm pre-eclampsia may help to prolong pregnancy (gestation), finds a study published by The BMJ today.

The findings show that pregnancy was prolonged by a week in the treatment group compared with the no treatment group, but the result was not statistically significant and therefore points to the need for further study.

If confirmed by future research, this could have important benefits for both mother and baby. 

Pre-eclampsia is a serious condition thought to be caused by the placenta not developing properly. Preterm pre-eclampsia (between 26-32 weeks’ gestation) often leads to early delivery, putting babies at risk of serious disability and death, particularly in low and middle-income countries.

Metformin is usually given to patients with diabetes to help control blood sugar levels, but preliminary studies suggest it could also be a potential treatment for pre-eclampsia. 

So researchers in Australia and South Africa set out to evaluate whether extended release metformin could be used to prolong gestation in women diagnosed with preterm pre-eclampsia.

The trial took place at a large hospital in Cape Town, South Africa and involved 180 pregnant women undergoing close monitoring (expectant management) for preterm pre-eclampsia.

Women were recruited between February 2018 and March 2020 when they were, on average, 29 weeks’ pregnant. None of them had diabetes or were currently using metformin or any other drugs that might interact with it.

Women were randomly split into two groups (arms): 90 received extended-release metformin and 90 received placebo daily, until delivery.

The average time from randomisation to delivery was 17.7 days in the metformin arm and 10.1 days in the placebo arm, an average difference of 7.6 days. However, this difference was not statistically significant.

Two more analyses were carried out. The first (in women who continued to take metformin at any dose) showed an average 9.6 day longer gestation, and the second (in women who took the full dose of metformin) showed an average 11.5 day longer gestation. Both these results were statistically significant.

There were no differences between the two arms in terms of serious birth complications or death among both mothers and babies. And no serious adverse events were observed, although diarrhoea was more common in the metformin arm.

This is a robust and well designed trial, but the researchers acknowledge some limitations. For example, this was a single centre study where the women had a high incidence of HIV, obesity, and chronic hypertension, so the results may not be more widely applicable.

Further trials of metformin should be considered to confirm whether the drug can statistically significantly prolong gestation and to evaluate the benefits to newborns, they say. However, based on the findings of this study, “we are cautiously optimistic that extended release metformin prolongs gestation in women with preterm pre-eclampsia.”

Tags : #DiabetesDrug #PretermPregnancies #Preeclampsia #Metformin

About the Author


Team Medicircle

Related Stories

Loading Please wait...

-Advertisements-


Trending Now

Is Liposuction surgery safe? Know the side effects of Liposuction Surgery May 21, 2022
The BD 'Advances in Clinical Flow Cytometry' Event provides clinicians with a rich knowledge-sharing platformMay 21, 2022
Omega 3 fatty acids – The essential fatMay 21, 2022
Vitamin B12 – Deficiency and sourcesMay 21, 2022
CDSCO has approved Boehringer Ingelheim's Jardiance for the treatment of heart failure.May 20, 2022
Hanuman raises over $.5 million to expand its emergency medical response services in Bihar, Jharkand and UP May 20, 2022
Sudden Infant Death Syndrome (SIDS) – Causes and preventive methodsMay 20, 2022
Healthcare Innovation Challenge: Data's Expanding Role in the Healthcare SectorMay 20, 2022
Homeopathy in Pregnancy - Homeopathy Treatment | MedicircleMay 20, 2022
MetroMedi launches the MetroMedi Relief platform for mental and sexual health wellbeing.May 20, 2022
Top Health Benefits for Butter milk May 20, 2022
Sumit Agarwal- Born with Cerabral Palsy to today being an acclaimed entrepreneur in the public relations industry in IndiaMay 20, 2022
Five eye hospitals in the Tri-city region have been acquired by Dr. Agarwal's Eye Hospital.May 19, 2022
World Family Doctor Day, 2022 – Family doctor makes care easily accessible May 19, 2022
Adani Enterprises will explore the healthcare industry.May 19, 2022
Tips for Weight Loss May 19, 2022
What should be the diet during menopause? May 19, 2022
5 Tips To Get Rid Of Cracked Heels In SummerMay 19, 2022
How is meditation beneficial in reducing low blood pressure?May 18, 2022
Why should we not eat mushrooms because of kidney disease? May 18, 2022