CytoDyn collaborates with amfAR to accelerate HIV cure research


Deprecated: strlen(): Passing null to parameter #1 ($string) of type string is deprecated in /home/medicircle/public_html/script_newsdetails.php on line 75
▴ CytoDyn collaborates with amfAR to accelerate HIV cure research
The amfAR Foundation for AIDS Research, to test the ability of Vyrologix (leronlimab) to mediate a functional HIV cure

CytoDyn Inc., a late-stage biotechnology company developing Vyrologix (leronlimab-PRO 140), a CCR5 antagonist with the potential for multiple therapeutic indications, announced today it signed an agreement with amfAR, The Foundation for AIDS Research, to test the ability of Vyrologix (leronlimab) to mediate a functional HIV cure. The international organization, amfAR, plays a vital role in AIDS research by identifying critical gaps in the knowledge of HIV and AIDS and supporting groundbreaking studies.

In 2007, Timothy Brown, also known as the “Berlin patient,” became the first documented person cured of HIV following a stem cell transplant from a CCR5-deficient donor. Subsequent attempts to cure HIV via stem cell transplant from donors expressing CCR5 failed, indicating the critical role of CCR5 deficiency in HIV cure. Last year, Adam Castillejo, formerly the “London patient,” became the second documented case of HIV cure after a stem cell transplant from a CCR5-deficient donor.

While it is now recognized that CCR5 is central to these two documented cases of HIV cure, natural CCR5-deficient individuals are rare and finding such donors is extremely difficult. Recently, Vyrologix (leronlimab) successfully protected macaques from retroviral infection, mirroring the protection from HIV seen in CCR5 deficient individuals. CytoDyn’s partnership with amfAR will advance clinical studies to incorporate Vyrologix to mimic a CCR5-deficient stem cell donor and attempt to functionally cure an HIV+ person receiving a stem cell transplant from a donor expressing CCR5.

“Using leronlimab to pharmacologically copy a CCR5-deficient donor for HIV cure is an exciting next step in our journey towards a cure for the 38 million people living with HIV,” stated Kevin Robert Frost, Chief Executive Officer at amfAR. “While a stem cell transplant is unlikely to be rolled out as an HIV cure, demonstrating that leronlimab can functionally phenocopy CCR5 deficiency and replicate the London and Berlin patients would be a major advancement.” As part of the agreement, CytoDyn will provide leronlimab and study support, while amfAR will support groundbreaking study sites to incorporate leronlimab in their cure studies.

Nader Pourhassan, Ph.D., President and Chief Executive Officer of CytoDyn, commented, “We are honored to be in partnership with amfAR and the opportunities to accelerate a search for an HIV cure using this scientific premise. Timothy Brown’s cure ignited hope that a cure can happen through bone marrow transplant from the rare individuals with a delta-32 mutation. The success in our animal studies for HIV with Vyrologix (leronlimab) has provided this opportunity. We are very excited to be supporting this project, and to be a part of this groundbreaking endeavor with amfAR.”

Tags : #CytoDynInc #LatestNewsonCytoDynInc24thNov #amfARFoundation #LatestNewsonamfARFoundation24thNov #LatestPharmaNews24thNov #LatestPharmaCollaboration24thNov #LatestResearchonAIDS #LatestResearonAIDS24thNov #BoneMarrowTransplant

About the Author


Team Medicircle

Related Stories

Loading Please wait...

-Advertisements-




Trending Now

Puja Curtains go up with KHUTI PUJA at Hazra Park DurgotsabJune 14, 2025
Medanta-Moolchand Heart Centre Expands Advanced Cardiac Care in South DelhiJune 14, 2025
Celebrating Every Gentle Touch — Himalaya BabyCare Unveils #GentleAsDad CampaignJune 14, 2025
Will we rise to #endAIDS challenge or stumble withering away the gains in HIV response?June 14, 2025
Wearable Biosensors in Diabetes Monitoring: A Patient Centric ApproachJune 14, 2025
Crack the Longevity Code: Why Flavonoid Variety Could Be the New Fountain of YouthJune 14, 2025
Why You Might Be Healthier Without Losing a Single KiloJune 14, 2025
The Great Unfollow: Why Patients Are Distrusting Influencer DoctorsJune 14, 2025
The Great Unfollow: Why Patients Are Distrusting Influencer DoctorsJune 14, 2025
Sleep Clinics Boom in Tier 2 Cities: What’s Fueling the Demand?June 14, 2025
Flight to Nowhere: The Air India Crash That Shook Ahmedabad and Raised Global Safety AlarmsJune 13, 2025
She Went for Pain Relief, Came Back With a Torn Artery: A Chiropractic Horror StoryJune 13, 2025
Biology vs Burnout: What Night Shifts Are Really Doing to Your Brain and BodyJune 13, 2025
Renowned Gynaecologist Joins Manipal Hospital Gurugram to Strengthen Women’s HealthJune 13, 2025
Aster CMI Hospital Saves Young Woman from Limb Loss in Rare Vascular SurgeryJune 13, 2025
QNET Unveils Father’s Day Gifts to Honour the Everyday Hero in Your LifeJune 13, 2025
Manipal Hospital Ghaziabad becomes first in the city to perform REZUM to treat prostate enlargementJune 13, 2025
Gen Z Doctors: Rethinking the White Coat Culture in IndiaJune 13, 2025
How Menopause Is Finally Becoming a Mainstream Medical ConversationJune 13, 2025
Thinner Bodies, Heavier Minds: When Diets Damage Mental HealthJune 13, 2025