Volta Labs launches fully automated, PCR-free workflow for whole genome sequencing

▴ Volta Labs launches
The automated, PCR-free workflow for whole genome sequencing (WGS) is set to revolutionize clinical research by reducing amplification bias, minimizing manual errors, and enhancing coverage in challenging GC-rich regions. This push-button solution boosts reproducibility, increases efficiency by 75–80% for laboratory staff, and makes high-quality, clinical-grade WGS accessible to mid-throughput laboratories.

At the Advances in Genome Biology and Technology (AGBT) General Meeting 2026, Volta Labs, a leader in next-generation sequencing (NGS) automation, has launched the Callisto Complete Kit for DNA EF Library Prep, a fully automated, PCR-free workflow for whole genome sequencing.

 

The new solution combines Watchmaker Genomics’ high-performance NGS chemistry with Volta’s digital fluidics platform, enabling labs to eliminate manual liquid handling, reduce operator variability, and generate reproducible, high-quality WGS libraries with minimal staffing burden.

 

Watchmaker Genomics Collaboration

As part of its product evolution, Volta Labs also introduced the Callisto™ Complete Kit for DNA EF Library Prep, Powered by Watchmaker Genomics. The fully automated solution delivers PCR-free whole genome sequencing with minimal hands-on time, high reproducibility, and strong performance across challenging inputs.

This launch represents a major step forward in making highest quality WGS accessible without increasing staffing burden or workflow complexity.

With new collaborations spanning Roche and Watchmaker Genomics™ Volta Labs is expanding the capabilities of its Callisto™ platform — transforming sequencing from manual workflow development to true push-button execution.

 

The Shift to Apps-Based Genomics

Volta Labs also unveiled a growing pipeline of pre-developed applications rolling out through 2026 — advancing its vision of an apps-based model for genomics, where validated workflows replace repeated, costly method development.

"Sequencing innovation shouldn't require every lab to reinvent the workflow," said Udayan Umapathi, CEO of Volta Labs. "We're accelerating the industry's shift toward truly automated genomics — where push-button sequencing becomes the standard, not the exception."

Tags : #BiotechInnovation #LifeSciences #PrecisionMedicine #ResearchInnovation #GeneticResearch #MolecularBiology #LabAutomation #smitakumar #medicircle

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