Thursday, October 08, 2026
A Make-in-India innovation taking mangoes into next-generation cognitive health solutions.
Hyderabad, 28th January 2026: Zeus Hygia Lifesciences, a science-led nutraceutical ingredient innovator, today announced the launch of STADICE, a proprietary, enriched Mango extract designed to support cognitive performance, alertness, focus, and memory. Developed using Zeus Hygia’s proprietary Insolib™️ Technology, STADICE® addresses the long-standing solubility and bioavailability challenges associated with conventional Mango or mangiferin extracts. STADICE® transforms mangiferin from a promising molecule into a practical, high performance cognitive ingredient.
The global demand for cognitive health solutions is rising rapidly, driven by increasing screen time, high-performance work environments, stress, and the rapid growth of e-sports and competitive gaming. There is a growing need for supplements that can support sustained focus, mental energy, and alertness throughout the day. Backed by clinical findings, STADICE® is a plant-based ingredient designed to meet these modern cognitive demands by helping individuals stay focused and mentally energised across extended periods of performance.
Mangiferin: Benefits and Limitations of Conventional Mango Extracts
Mangiferin is a naturally occurring polyphenol derived from the bark of mango tree (Mangifera indica), traditionally used in Ayurveda and widely studied for its neuroprotective, antioxidant, and stress-modulating properties. Scientific literature highlights mangiferin’s ability to support memory, attention, mental clarity, and resilience against oxidative stress.
However, despite its strong biological potential, conventional mangiferin extracts face significant limitations:
These challenges have historically restricted mangiferin’s effectiveness in cognitive health products.
The global demand for cognitive health solutions is rising rapidly, driven by increasing screen time, high-performance work environments, stress, and the rapid growth of e-sports and competitive gaming. There is a growing need for supplements that can support sustained focus, mental energy, and alertness throughout the day. Backed by clinical findings, STADICE® is a plant-based ingredient designed to meet these modern cognitive demands by helping individuals stay focused and mentally energised across extended periods of performance.
Mangiferin: Benefits and Limitations of Conventional Mango Extracts
Mangiferin is a naturally occurring polyphenol derived from the bark of mango tree (Mangifera indica), traditionally used in Ayurveda and widely studied for its neuroprotective, antioxidant, and stress-modulating properties. Scientific literature highlights mangiferin’s ability to support memory, attention, mental clarity, and resilience against oxidative stress.
However, despite its strong biological potential, conventional mangiferin extracts face significant limitations:
- Poor aqueous solubility, especially in acidic environments
- Low intestinal permeability and absorption
- Classification as a BCS Class IV compound (low solubility, low permeability)
- Reduced oral bioavailability, limiting clinical efficacy
- Inconsistent performance in finished formulations
These challenges have historically restricted mangiferin’s effectiveness in cognitive health products.
STADICE: A Science-Led Breakthrough in Mango Extract (Mangiferin) Delivery
Unlike many traditional cognitive botanicals such as Ashwagandha, Bacopa monnieri, Ginkgo biloba, and Centella asiatica which often suffer from poor solubility and bitter taste profiles. STADICE® addresses the two most critical formulation challenges in cognitive botanicals: poor solubility and bitter taste by offering a neutral sensory profile, excellent water solubility, and superior formulation flexibility. Powered by Zeus Hygia’s proprietary Insolib™ Technology, STADICE® enhances the solubility and dissolution behavior of mangiferin across a wide pH range, resulting in improved bioavailability compared to conventional mangiferin extracts.
STADICE® is supported by human clinical data conducted on 60 subjects at a 300 mg daily dose over 7 days, showing statistically meaningful improvements across multiple cognitive markers, including mental speed, focused attention, working memory, sustained attention, and auditory verbal learning, highlighting STADICE® as a fast-acting solution for modern cognitive demands.
Literature indicates that mangiferin can cross the blood-brain barrier and support cognitive health through antioxidant, anti-inflammatory, and neuroprotective pathways. STADICE supports brain function by reducing oxidative stress, preserving mitochondrial function, modulating neurotransmitter activity, and supporting brain-derived neurotrophic factor (BDNF), which plays a key role in learning, memory, and stress regulation.
“Cognitive fatigue, stress, and reduced attention are no longer niche concerns; they are everyday realities across age groups and professions,” said Dr. Arunkanth Krishnakumar, Co-founder and CEO, Zeus Hygia Lifesciences. “With STADICE, our focus was to unlock the true potential of mangiferin through science-led innovation. By improving its solubility and bioavailability, we’ve created an ingredient that delivers faster, more consistent cognitive benefits while remaining rooted in botanical science.”
STADICE® is now available for global B2B partnerships, with commercial samples and technical dossiers available to qualified partners across the nutraceutical, pharmaceutical, and functional nutrition ecosystem, with wide-ranging applications in cognitive health and brain wellness supplements, e-sports and gamer-focused nutrition, stress, focus, and alertness formulations, as well as products designed for students, working professionals, and ageing populations. Developed in DSIR-approved scientific laboratories and manufactured at a USFDA-registered facility, STADICE® reflects Zeus Hygia’s commitment to clinically validated, science-first innovation.
Unlike many traditional cognitive botanicals such as Ashwagandha, Bacopa monnieri, Ginkgo biloba, and Centella asiatica which often suffer from poor solubility and bitter taste profiles. STADICE® addresses the two most critical formulation challenges in cognitive botanicals: poor solubility and bitter taste by offering a neutral sensory profile, excellent water solubility, and superior formulation flexibility. Powered by Zeus Hygia’s proprietary Insolib™ Technology, STADICE® enhances the solubility and dissolution behavior of mangiferin across a wide pH range, resulting in improved bioavailability compared to conventional mangiferin extracts.
STADICE® is supported by human clinical data conducted on 60 subjects at a 300 mg daily dose over 7 days, showing statistically meaningful improvements across multiple cognitive markers, including mental speed, focused attention, working memory, sustained attention, and auditory verbal learning, highlighting STADICE® as a fast-acting solution for modern cognitive demands.
Literature indicates that mangiferin can cross the blood-brain barrier and support cognitive health through antioxidant, anti-inflammatory, and neuroprotective pathways. STADICE supports brain function by reducing oxidative stress, preserving mitochondrial function, modulating neurotransmitter activity, and supporting brain-derived neurotrophic factor (BDNF), which plays a key role in learning, memory, and stress regulation.
“Cognitive fatigue, stress, and reduced attention are no longer niche concerns; they are everyday realities across age groups and professions,” said Dr. Arunkanth Krishnakumar, Co-founder and CEO, Zeus Hygia Lifesciences. “With STADICE, our focus was to unlock the true potential of mangiferin through science-led innovation. By improving its solubility and bioavailability, we’ve created an ingredient that delivers faster, more consistent cognitive benefits while remaining rooted in botanical science.”
STADICE® is now available for global B2B partnerships, with commercial samples and technical dossiers available to qualified partners across the nutraceutical, pharmaceutical, and functional nutrition ecosystem, with wide-ranging applications in cognitive health and brain wellness supplements, e-sports and gamer-focused nutrition, stress, focus, and alertness formulations, as well as products designed for students, working professionals, and ageing populations. Developed in DSIR-approved scientific laboratories and manufactured at a USFDA-registered facility, STADICE® reflects Zeus Hygia’s commitment to clinically validated, science-first innovation.
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